History of Biomedical Research - 1970's

Animal Research Was Essential in the Following Developments:

• Discovery of cimetidine for ulcers
• Treatment for leprosy
• Development of hepatitis B vaccine
• Advances in cardiology (measuring of coronary blood flow; myocardial preservation; heart transplant refined; coronary bypass surgery)
• Prevention of measles
• Identification of feline leukemia virus
• Eradication of Venezuelan equine encephalitis and hog cholera
• Discovery of the link between cholesterol and heart disease

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Nobel Prizes in Medicine Which Involved Animal Models:

Year	Scientist/s	Animal/s Used	Contribution Made
1970	Katz, von Euler, Axelrod	Cat, rat	Mechanisms of storage and release of nerve transmitters.
1971	Sutherland	Rat	Mechanism of the actions of hormones
1972	Edelman, Porter	Guinea pig, rabbit	Chemical structure and nature of antibodies
1973	von Frisch, Lorenz, Tinbergen	Bird, bee	Organization of social and individual behavior patterns in animals.
1974	de Duve, Palade, Claude	Chicken, guinea pig, rat	Structural and functional organization of cells
1975	Baltimore, Dulbecco, Temin	Monkey, horse, chicken, mouse	Interaction between tumor viruses and genetic material.
1976	Blumberg, Gajdusek	Chimpanzee	Slow viruses and new mechanism for dissemination of diseases.
1977	Guiltemin, Schally, Yalow	Sheep, pig	Role of hypothalamic hormones in the body
1979	Cormack, Hounsfield	Pig	Development of computer-assisted tomography (CAT scan)